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Why Stress, Particularly at Work, Determines Whether Nutrition Works or Fails

By Michael J. Critelli | MakeUsWell Newsletter, 


Most discussions of nutrition, particularly in corporate settings, assume a simple equation: better food choices lead to better health, energy, and productivity. Cafeterias are upgraded, wellness apps are offered, and employees and other consumers are encouraged to “eat healthier.” Yet many organizations and individuals see little improvement in metabolic health, fatigue, or healthcare costs, even among highly motivated professionals.

The reason is uncomfortable but increasingly clear: stress, particularly at work, often determines whether nutrition helps or harms.

Food does not operate in a vacuum. The body’s response to what we eat is shaped by the internal signals it receives at the moment of eating, and those signals are heavily influenced by stress, sleep, and workload design. In many workplaces, stress quietly overrides nutrition.

A simple explanation of what’s really happening

When people eat, their bodies must decide what to do with that fuel. Use it immediately? Store it? Build muscle? Protect against perceived threat?

Those decisions are guided by hormones: essentially internal text messages telling the body how safe or threatened it is.

  • In a low-stress state, the body is willing to use food for energy, repair, and long-term health.
  • In a high-stress state, the body becomes defensive. It prioritizes quick energy and storage, even if the food itself is “healthy.”

This is why two people can eat the same lunch and experience different outcomes. The difference is not discipline or knowledge. It is the stress environment surrounding the individual..

How workplace stress makes nutrition work worse

Chronic workplace stress, tight deadlines, constant interruptions, unclear priorities, long hours, late-night emails, and, to a greater extent than ever, the fear of losing a job to an AI-infused alternative, keeps the body in a prolonged state of alert.

In that state:

  • Blood sugar rises more easily
  • Insulin works less efficiently
  • Fat storage is favored, especially around the abdomen
  • Muscle repair and metabolic flexibility decline

The practical result is counterintuitive but common: employees who eat well still gain weight, lose energy, and feel mentally foggy. Nutrition is not failing because food is wrong. It is failing because stress changes how food is processed.

Late lunches eaten while multitasking, dinners consumed after 10 p.m., and caffeine-fueled workdays followed by short sleep compound the problem. Even high-quality meals are metabolically “misread” by a stressed system.

How the same workplace can make nutrition work better

The inverse is equally true, and far less discussed.

When workplace stress is managed intelligently, nutrition becomes dramatically more effective without changing food choices. Lower stress improves how the body uses food, not just what food is chosen.

In lower-stress environments:

  • Blood sugar responses flatten
  • Appetite regulation improves naturally
  • Energy lasts longer after meals
  • Cravings decrease without willpower
  • Muscle maintenance improves, even with aging

This explains why people often experience health improvements on vacation without changing what they eat very much. The stress signal changes, and food suddenly “works.”

Timing, recovery, and work design matter more than menus

From a leadership perspective, the most powerful nutrition interventions rarely look like nutrition interventions at all.

They include:

  • Predictable work rhythms that allow regular meals
  • Reduced late-night communication expectations
  • Protected recovery time after intense work periods
  • Fewer unnecessary urgencies that keep stress chronically elevated
  • More thoughtful, caring and intelligent attentiveness to both the intended and unintended consequences of leadership words and actions.

Even small improvements in these areas can make existing nutrition programs far more effective.

Conversely, organizations that promote healthy eating while maintaining constant urgency and fear inadvertently undermine their own investments. They are asking food to fix what stress is breaking.

Why this matters for productivity and cost

Metabolic stress does not stay confined to waistlines or lab values. It shows up as:

  • Afternoon energy crashes
  • Reduced cognitive endurance
  • Slower recovery from illness
  • Increased musculoskeletal complaints
  • Rising healthcare utilization

These outcomes are often attributed to aging or individual lifestyle choices. In reality, they are frequently system-level stress effects, amplified by how nutrition is processed under pressure.

Reframing for CEOs and others in leadership positions

For CEOs and other senior  leaders, the critical insight is this:

Nutrition success is not primarily a personal responsibility problem. It is a signaling environment problem, and leaders shape the signaling environment.

Workplace stress can either:

  • Turn good nutrition into fuel for resilience and performance 

                                                   or

  • Turn good nutrition into stored energy, fatigue, and inflammation

That choice is made not in the cafeteria, but in how work is structured, paced, and led.

When executives understand this, wellness stops being a side program and becomes part of operational design. The goal shifts from telling employees to “eat better” to creating conditions where eating better actually works.

That is not just a health strategy. It is a leadership one.

The broader implications of this research.

Historically, workplaces were the major sources of stress. Regrettably, the stress from social media, political and social-cultural divisions, and the sense that external events are outside our control are a stress multiplier. 

That is why CEOs and other leaders have an even bigger opportunity and challenge to make good nutritional choices and optimize potential. 


Why “Drink More Water” Isn’t Always Enough: The Case for Electrolytes

By Michael J. Critelli | MakeUsWell Newsletter, 


Recently, I had my routine periodic dental checkup here in Naples, FL. The technician told me that I appeared to have a “dry mouth,” and needed to refine the fluids I was ingesting. My physician advised me to increase the amount of electrolytes in my water or to increase them in some other way. This was a real eye opener for me, as it might be for others.

For decades, we’ve been told a simple rule of thumb for hydration: drink eight 8-ounce glasses of water a day. The familiar “64 ounces” guideline is easy to remember and generally helpful. But like many health slogans, it oversimplifies a more complex physiological reality—especially for people living or working in hot and humid environments like Florida.

In these conditions, hydration isn’t just about replacing water. It’s about replacing what we lose when we sweat. And that includes electrolytes.

Influence Without Guardrails: Why Nutrition on Social Media Needs an AI Check-and-Balance

By Michael J. Critelli | MakeUsWell Newsletter, 


Nutrition has always been a complex and contested field, but social media has fundamentally changed how nutritional ideas spread, and how quickly they harden into belief. Today, millions of people receive their primary nutrition guidance not from clinicians, registered dietitians, or peer-reviewed journals, but from influencers on TikTok, Instagram, YouTube, and podcasts. Some are thoughtful educators. Many are not. And the system in which they operate almost guarantees distortion.

This is not primarily a story about bad actors. It is a story about incentives, formats, and scale, and why artificial intelligence is increasingly necessary as a stabilizing counterweight.

COVID as a Metabolic Stress Test: What GLP-1 Therapies Reveal About Resilience Versus Emergency Medicine

By Michael J. Critelli | MakeUsWell Newsletter, 


Six years ago this month, we were becoming aware of the SARS-Cov-2 virus, later described as the COVID-19 pandemic. It is usually remembered as a sudden viral catastrophe that demanded unprecedented emergency responses. 

With the benefit of hindsight, however, it is equally accurate to describe COVID-19 as a metabolic stress test, one that revealed how profoundly baseline health shaped vulnerability to an acute infectious threat. The virus did not strike populations randomly. It exploited long-standing physiological weaknesses that had accumulated quietly for decades.

Few developments illuminate this reality more clearly than the later emergence of GLP-1 receptor agonists as powerful therapies for obesity, insulin resistance, and related cardiometabolic conditions. These medications were not widely available during the pandemic’s early years, but their rise helps clarify what kind of resilience was missing in 2020, and why emergency medicine alone could not fully compensate for it.

A Most Impactful New Year’s Resolution: My 1977 Journey

By Michael J. Critelli | MakeUsWell Newsletter, 


At the end of 1976, I was deeply unhappy with what I saw when I looked in the mirror in my Evanston, Illinois apartment. I was about 25 pounds overweight. My skin looked pale. I had low energy and poor stamina. 

For someone who had once been a long-distance runner in high school and routinely played long singles tennis matches, it was humbling that I could barely jog a block without getting winded. My clothes were very tight around the waist and starting to look worn, which made me appear heavier than I actually was. For the first and only time in my life, I decided to make a New Years resolution to lose weight and be more fit.  

I also had an external motivation. Two months earlier, I had met the woman I would eventually marry, Joyce McNagny, in court. But I felt that if I asked her out then, I would be rejected because of how I looked and felt. I still would have made the resolution, but looking better for her was certainly a powerful additional impetus to succeed.